HBsAg – поверхностный антиген есть у нас, HBeAg – ядерный, маркер репликации активной… ну, и далее, антитела. Итак, посмотрим на возможности серологии тут:

Все мимо…

ОК, так что же у нас по диагностике оккультного гепатита B (OBI)?

Diagnosis
The gold standard for diagnosis of OBI became possible by highly sensitive and specific molecular biology techniques like HBV nucleic acid amplification testing (NAT), a PCR technique with detection limits of <10 copies HBV DNA per reaction [3]. Samples for analysis include specimens from the liver and blood but diagnosis of OBI most commonly is based on the analysis of serum samples, because liver specimens are only available in a minority of cases and standardized assays for use in liver tissue are not yet available [3]. If highly sensitive HBV DNA testing is not feasible, anti-HBc should be used as a less than ideal surrogate marker for identifying potential seropositive OBI individuals in cases of blood, tissue, or organ donation, and when immune suppressive therapy has to be administered [6]. In this context, it has to be stressed that not all anti-HBc-positive individuals are found to be HBV DNA positive and that anti-HBc tests may provide false positive results [7].

OBI is more often detected in patients positive for anti- HBc but negative for anti-HBs, presumably because these patients lack the neutralizing effect of anti-HBs [8]. Most frequently, seropositive occult HBV infection follows resolution of acute hepatitis and continues indefinitely after clearance of HBsAg and biochemical improvement in liver function; it can also occur after years of chronic HBsAg-positive infection [9, 10]. OBI must be differentiated from S-escape mutants infection, in which undetectable HBsAg is present in spite of the episomal, free HBV genomes at intrahepatic level as in overt infection. These cases (so-called false occult HBV) result from HBV strains with key mutations in pre-S region which is not recognized by commercially available kits, even when the most sensitive ones are used [11].

False OBI has been reported in up to 40% of patients with OBI [3, 11–13]. In the HBsAg assays, the use of multivalent anti-HBs antibodies is recommended for detection of false OBI [3].

Mehdi Zobeiri, “Occult Hepatitis B: Clinical Viewpoint and Management”, Hepatitis Research and Treatment, vol. 2013, Article ID 259148, 7 pages, 2013. https://doi.org/10.1155/2013/259148

Как видим, никаких антигенов, что логично, если уже и антигены любые поймать можно, то что мешает поймать тогда ДНК? ПЦР ультрачевствительный и лучше биоптат печени, ок, хотя бы кровь. Остальное – полумеры и не окончательно.

просто в лабе сказали нельзя курить и даже жвачку

Какие ответственные администраторы и лаборанты иногда бывают )

курил не

Вирусы то же на перекур выходят.
Устают.😁🤣🤣