Results
Among 83,893 PWH, there were 5,628 incident cancers, including lung cancer (n = 755), Kaposi sarcoma (KS, n = 501), non-Hodgkin lymphoma (NHL, n = 497), and anal cancer (n = 439). Median age at cohort entry was 43 years. Overall median six-month lagged CD4/CD8 ratio was 0.52 (interquartile range: 0.30–0.82). Compared with a six-month lagged CD4/CD8 of 0.80, a CD4/CD8 of 0.30 was associated with increased risk of any incident cancer (adjusted hazard ratio = 1.24 [95%CI: 1.14–1.35]). CD4/CD8 ratio was also inversely associated with NHL, KS, lung cancer, anal cancer, and colorectal cancer in adjusted analyses (all 2-sided p < 0.05). Results were similar using 12-, 18-, and 24-month lagged CD4/CD8 values.

То есть в среднем, берем много, и на 100 всяких онко при соотношении 0,8 будет 124 при соотношении 0,3. Ну, все логично, и 0,3 и 0,8 – большая разница, а вот 100 и 124 – не очень. Риски выше, но даже при существенной разнице – не столь драматически, не кратно, как минимум, и близко.